Does Fisetin Really Fight Aging?

Does Fisetin Really Fight Aging? Nine Hard-Earned Evidence?

The "Garbage Truck" of Aging Cells

In 2018, EBioMedicine conducted an experiment in which 75-year-old mice were given fisetin powder for five consecutive days. The "aging signal lights" p16 in the kidneys, liver, and fat of mice were completely turned off, significantly extending their lifespan by 10%.

Antioxidant + Telomere Protection

It contains four "fire-extinguishing hydroxyl groups" that extinguish free radicals. It also fully upgrades the body's three firefighting forces: SOD, CAT, and GSH-Px, instantly slowing down the rate at which telomeres are eroded.

Activating the Dual Longevity Pathways of AMPK/SIRT1

Tested in yeast, nematodes, fruit flies, and mice, Fisetin can effectively push the "dietary longevity" button, conserving energy and recycling waste.

Putting the Brakes on Inflammation

Chronic inflammation is one of the seven main culprits of aging. Fisetin inhibits NF-κB signaling, causing TNF-α, IL-6, and IL-1β levels to plummet. Inflammatory factors in the serum of 70-week-old mice plummet to the level of an 8-week-old.

Skin Collagen "Recharge"

Ultraviolet rays want to break down collagen? First, let fisetin do it. While suppressing MMP-1 and MMP-3, it also prompts TGF-β/Smads to work overtime to produce collagen, saying goodbye to fine lines and looseness.

The brain also benefits

Alzheimer's mice fed fisetin showed fewer β-amyloid plaques, improved their memory tests, and rejuvenated their brains.

Metabolism Rejuvenation

Overweight mice fed a low-dose fisetin for six weeks showed improved insulin sensitivity, less fatty liver, and adipose tissue that turned brown, burning calories—truly a metabolic powerhouse. Early human trials
Nineteen volunteers took 500 mg/day for six months, and their DNA methylation clock was set back 1.48 years. While the sample size is small, it's large enough to excite scientists.
Safety Briefs
A Phase I trial at the University of Minnesota reported no significant problems with single doses of 100-2000 mg, with only a few stomach rumblings in the high-dose group. This gave researchers confidence to continue the study.

Is it okay to use fisetin topically?

Fisetin powder can be used as a substance for applying to the skin.

Although the skin's stratum corneum acts as a barrier, the alcohol-propylene glycol-liposome complex system allows fisetin to penetrate the skin at a coefficient of 2.3×10⁻³ cm/h, sufficient to achieve μM concentrations in the dermis.

Topical fisetin cream (0.1%-0.5%) absorbs less than 5% into the systemic circulation through the skin, yet it can achieve localized blood concentrations 10-20 times those achieved with oral administration, providing precise protection against photoaging.

In vitro studies have shown that the combined use of 0.1% fisetin and 0.05% retinol stimulates collagen synthesis by 27% compared to either alone, while also reducing the irritation of retinol.

How to Choose Reliable Fisetin Powder?

1. Purity and Testing
HPLC ≥98%, heavy metal content <10 ppm, microbial content meets USP standards. Suppliers should provide a Certificate of Authenticity (COA), MSDS, and stability report.

2. Crystal Form and Processing
Prefer yellow needle-shaped crystals over amorphous powder. Form I offers better solubility and stability. Inquire whether a three-step process of alcohol extraction, macroporous resin purification, and recrystallization is used to avoid residual organic solvents.

3. Packaging and Shipping
Packed in vacuum-filled, nitrogen-filled aluminum foil bags, covered with aluminum drums. Transport at room temperature, away from light. Ice packs should be added in summer to prevent polymerization at high temperatures.

4. Reliable Supplier: sost biotech. Contact Email: ericyang@xasost.com