How does cis-15-tetracosenoic acid stimulate collagen synthesis?

As researchers working on skin aging prevention, we fully understand that collagen degradation is a major cause of skin aging. In recent years, due to its unique molecular mechanism, cis-15-tetracosenoic acid (nervonic acid) has become a growing ingredient in cosmetic and skin care products.

How is the molecular machinery of cis-15-tetracosenoic acid used to stimulate collagen synthesis?

Cis-15-tetracosenoic acid does not act as a dietary supplement, but regulates collagen metabolism through multiple targeted pathways. According to current research, its central mechanism of action lies in the activation of the TGF-β/Smad pathway, a known important regulatory pathway for collagen synthesis.

When cis-15-tetracosenoic acid is absorbed by the fibroblast membrane, the two cis-bond structures provide a unique flexibility that allows it to penetrate the phospholipid layer of the cell membrane. Activation of Smad 2/3 proteins forms a complex that enters the cell nucleus, binds directly to the promoter region of the type I collagen gene, and initiates transcription. This process not only accelerates collagen synthesis, but also ensures the structural integrity of the newly synthesized collagen.

Above all, its combined mechanism of action is remarkable: this substance stimulates the production of EOS ceramide, strengthening the "bricks and mortar" structure of the hair shaft. A healthy epidermal barrier significantly reduces transdermal water loss (TEWL), maintains a moist environment in the epidermis, and creates favorable conditions for the effective functioning of fibroblasts. The dual processing mechanism of "external protection and internal improvement" provides superior results for single-channel operators.

Moreover, the anti-inflammatory effect of cis-15-tetracoecanoic acid indirectly protects collagen. It inhibits the release of inflammatory factors such as TNF-α and IL-6, thereby reducing the activity of matrix metalloproteinases (MMPs) and degrading existing collagen fibers. This dual mechanism of "promoting synthesis + resisting degradation" makes it particularly useful in preventing aging.

What are the advantages of cis-15-tetracoecanoic acid over traditional anti-aging agents?

In the oral cosmetic market, products such as vitamin C show the various effects of cis-15-tetracoecanoic acid in three ways:

First, more targeted. Vitamin C mainly stabilizes proline hydroxylase through the collagen trimerization catalysis; Pro-xylan supports the collagen network by promoting glycosaminoglycan synthesis. However, cis-15-tetracosanoic acid acts directly on the TGF-β/Smad signaling axis, which is a “master switch” for collagen synthesis, resulting in high regulatory efficiency.

Second, the use of specialized cells. As a long-chain fatty acid containing 24 carbon atoms, its cis structure allows it to maintain bioavailability at body temperature of 37°C, with a gastrointestinal absorption rate of over 85%. In contrast, the absorption rate of large molecular weight collagen peptides can vary from 60-80% due to differences in molecular weight. After being absorbed, cis-15-tetracoechanoic acid can directly participate in the structural organization of the cell membrane and quickly enter the site of action.

Third, it provides greater efficacy. In addition to stimulating collagen production, it can also simultaneously improve the skin's protective function, improve the health of the sebaceous glands, and improve blood circulation in the body. This means that one product can have three main effects: brightening, moisturizing, and hydrating the skin. For the brand, this "multiple benefits at once" feature provides a significant competitive advantage in cost control.

Professional Supply Chain Solutions: Sost Biotech Helps You Seize Market Opportunities

As a supplier with years of experience in the functional raw materials field, Sost Biotech focuses on the R&D and production of high-purity cis-15-tetracoeconic acid powder, providing one-stop solutions for oral beauty, functional food, and high-end skincare brands.

Core Advantages:

Purity Guarantee: Utilizing patented synthesis technology, the cis isomer content is ≥99%, far below the industry benchmark of 90%, ensuring maximum pharmacological activity.

Quality Control: Each batch of products comes with triple testing reports (HPLC, GC-MS, NMR), and indicators such as heavy metals, microorganisms, and solvent residues comply with USP/EU standards.

Technical Support: Providing full-process technical guidance from formulation design and stability testing to regulatory application.

Sost Biotech not only provides high-quality raw materials but is also committed to working with clients to develop competitive end products.

Brands and R&D institutions are welcome to request free samples and detailed test reports. Our technical team will provide you with personalized solutions.

Email: ericyang@xasost.com