Nobiletin Powder

Nobiletin powder is a flavonoid compound extracted from plants of the genus Citrus in the Rutaceae family (such as dried tangerine peel), which has biological activities such as antioxidation, anti-inflammation and cardiovascular protection. Currently, it is mainly applied in the fields of pharmaceuticals, health products and food additives, and its mechanism of action and safety are still under study.

Prevent Alzheimer's disease-type cognitive impairment
Alzheimer's syndrome is the most common type of dementia. When it occurs, the number of nerve cells in the brain sharply decreases, and the brain atrophies, causing problems such as cognitive impairment and intellectual disability.The representative feature of Alzheimer's disease is age spots, which are caused by excessive accumulation of beta-amyloid protein.While reducing beta-amyloid protein in the brain, nobiletin can also decrease the deposition of age spots.Nobiletin can also activate the signal cell information transmission molecules that play an important role in the extension of nerve cells. Therefore, it can be said that nobiletin has the effect of preventing Alzheimer's disease.

Inhibit the rise of blood sugar levels
Nobiletin can promote the secretion of adiponectin by adipocytes. Adiponectin can enhance insulin resistance and inhibit insulin secretion. Its preventive effect on diabetes is worth looking forward to.

Prevention of metabolic syndrome
Nobiletin also has the effect of promoting the differentiation of adipocytes and the decomposition of fat within adipocytes.Moreover, it can inhibit the rise of blood sugar levels and blood pressure, and can be considered to have the effect of preventing metabolic syndrome.

Reduce inflammation and relieve pain
Inflammation, especially chronic inflammation, is closely related to lifestyle diseases such as metabolic syndrome and arteriosclerotic diseases.Nobiletin powder can activate proteins related to chronic inflammation, thereby suppressing inflammation and relieving pain.

The best source of nobiletin is the peels of rutaceae plants, including those of Sichuan tangerine (Citrus nobilis Lour.), lime (C.aurantium L.), as well as the leaves and stems of citrus (C.reticulata Blanco).Among them, Sichuan red tangerine, as the sole source species of Sichuan dried tangerine peel, the medicinal components of Sichuan dried tangerine peel made from its peel are higher and more popular in the market.

Citrus reticulata (Mandarin Oranges): This variety is known to have high levels of nobiletin.
Citrus sinensis (Oranges): Oranges, particularly the peel, are another rich source of nobiletin.
Citrus tangerine (Tangerines): Tangerines are also known to contain high concentrations of nobiletin.
Other Citrus Fruits: While nobiletin is found in the peels of grapefruit, lemons, and limes, the specific concentrations may vary.

Nobiletin powder is mainly found in citrus fruits such as dried tangerine peel and can be consumed directly or after processing.For instance, dried tangerine peel is the main source of nobiletin, and its active ingredients can be ingested through methods such as making tea or stewing soup.‌
Pharmaceutical preparations: Nobiletin is often made into tablets, capsules and other dosage forms and is used for medical purposes such as anti-inflammation and cardiovascular protection.‌
Functional foods: Some foods (such as health supplements) may contain extract of nobiletin from sichuan, which is taken orally.